Humanin vs Spermidine
A side-by-side research comparison of Humanin and Spermidine across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Humanin | Spermidine |
|---|---|---|
| Full name | Humanin (HN) Mitochondrial-Derived Peptide | Spermidine (Polyamine) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Dietary compound (research ongoing) |
| Mechanism | Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection. | Induces autophagy, partly by inhibiting acetyltransferase activity and mimicking caloric restriction signaling. This promotes clearance of damaged proteins and organelles, supporting cellular renewal, cardiovascular health, and cognition. |
| Molecular weight | 2,687 Da | 145.25 Da |
| Half-life | 4-6 hours | Short; rapidly absorbed and distributed |
| Bioavailability | Moderate (SubQ) | Oral absorption reported; also produced by gut bacteria |
| Typical dose | 1-5 mg | 1-10 mg per day |
| Frequency | 3-5x per week | Once daily |
| Route | Subcutaneous | Oral |
Humanin reported benefits
- Neuroprotection against amyloid-beta
- Anti-apoptotic
- Improved insulin sensitivity
- Cardioprotection
- Cellular stress resistance
Spermidine reported benefits
- Induces autophagy (cellular clean-up)
- Cardiovascular support
- Cognitive and memory support (research)
- May support hair and overall longevity
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Research and educational reference only. Not medical advice.