Glutathione vs Humanin
A side-by-side research comparison of Glutathione and Humanin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Glutathione | Humanin |
|---|---|---|
| Full name | L-Glutathione (Reduced) | Humanin (HN) Mitochondrial-Derived Peptide |
| Category | Anti-Aging | Anti-Aging |
| Status | Supplement / Injectable | Research compound |
| Mechanism | Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA. | Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection. |
| Molecular weight | 307.32 Da | 2,687 Da |
| Half-life | ~1.5-2 hours (IV/IM) | 4-6 hours |
| Bioavailability | ~95% injectable; low oral (~3%) | Moderate (SubQ) |
| Typical dose | 200-600 mg | 1-5 mg |
| Frequency | 1-3x per week | 3-5x per week |
| Route | IV push, IM injection, or nebulized | Subcutaneous |
Glutathione reported benefits
- Powerful antioxidant protection
- Liver detoxification support
- Skin brightening
- Immune system support
- Anti-aging cellular protection
- Heavy metal chelation
Humanin reported benefits
- Neuroprotection against amyloid-beta
- Anti-apoptotic
- Improved insulin sensitivity
- Cardioprotection
- Cellular stress resistance
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Research and educational reference only. Not medical advice.