Humanin vs Urolithin A
A side-by-side research comparison of Humanin and Urolithin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Humanin | Urolithin A |
|---|---|---|
| Full name | Humanin (HN) Mitochondrial-Derived Peptide | Urolithin A (Mitophagy Activator) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Dietary compound (clinical studies) |
| Mechanism | Binds IGFBP-3, BAX, and trimeric receptor (CNTFR/WSX-1/gp130) to activate STAT3. Inhibits mitochondrial apoptosis and provides neuroprotection. | Stimulates mitophagy - the selective recycling of damaged mitochondria - improving mitochondrial quality and energy efficiency in muscle and other tissues. |
| Molecular weight | 2,687 Da | 228.20 Da |
| Half-life | 4-6 hours | Several hours |
| Bioavailability | Moderate (SubQ) | Oral; bypasses the need for the gut bacteria many people lack |
| Typical dose | 1-5 mg | 500-1000 mg per day |
| Frequency | 3-5x per week | Once daily |
| Route | Subcutaneous | Oral |
Humanin reported benefits
- Neuroprotection against amyloid-beta
- Anti-apoptotic
- Improved insulin sensitivity
- Cardioprotection
- Cellular stress resistance
Urolithin A reported benefits
- Improves mitochondrial function (mitophagy)
- Increased muscle endurance
- Cellular energy support
- Studied for healthy aging
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Research and educational reference only. Not medical advice.