NAC vs Quercetin
A side-by-side research comparison of NAC and Quercetin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | NAC | Quercetin |
|---|---|---|
| Full name | N-Acetyl Cysteine | Quercetin (Flavonoid Senolytic) |
| Category | Detox & Antioxidant | Detox & Antioxidant |
| Status | Dietary supplement / FDA-approved (Mucomyst) | OTC supplement |
| Mechanism | Provides cysteine for glutathione synthesis (rate-limiting step). Directly scavenges free radicals via sulfhydryl group. Chelates mercury, lead, and arsenic. Modulates glutamate via system Xc- transporter for neuropsychiatric effects. | Selectively induces apoptosis in senescent cells by inhibiting pro-survival (SCAP/BCL) pathways, especially when paired with dasatinib. Also scavenges free radicals, inhibits mast-cell histamine release, and modulates NF-kB inflammatory signaling. |
| Molecular weight | 163.19 Da | 302.24 Da |
| Half-life | ~5.6 hours | ~11-28 hours |
| Bioavailability | ~6-10% oral (poor but effective due to GSH replenishment) | Low; improved by phytosome/bromelain formulations |
| Typical dose | 600-1800 mg | 500-1000 mg per day (daily) or high-dose pulsed (senolytic) |
| Frequency | 1-2x daily | Daily or intermittent |
| Route | Oral capsule or IV (hospital) | Oral capsule |
NAC reported benefits
- Glutathione replenishment
- Liver protection (acetaminophen, alcohol)
- Heavy metal chelation
- Mucus thinning (respiratory)
- OCD/addiction support
- Anti-inflammatory
Quercetin reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Natural antihistamine
- Cardiovascular support
- Immune modulation
- Synergy with fisetin/dasatinib
Related comparisons
Research and educational reference only. Not medical advice.