NAC (N-Acetyl Cysteine)
The rate-limiting precursor to glutathione synthesis. NAC replenishes intracellular GSH, protects the liver from oxidative damage, breaks down mucus, and chelates heavy metals. Also researched for OCD, addiction, and neuroinflammation.
How it works
Provides cysteine for glutathione synthesis (rate-limiting step). Directly scavenges free radicals via sulfhydryl group. Chelates mercury, lead, and arsenic. Modulates glutamate via system Xc- transporter for neuropsychiatric effects.
Key facts
- Molecular weight: 163.19 Da
- Half-life: ~5.6 hours
- Bioavailability: ~6-10% oral (poor but effective due to GSH replenishment)
- Storage: Room temperature. Protect from moisture (hygroscopic).
Dosing overview
- Typical dose: 600-1800 mg
- Frequency: 1-2x daily
- Duration: Ongoing or cycles
- Route: Oral capsule or IV (hospital)
Reported benefits
- Glutathione replenishment
- Liver protection (acetaminophen, alcohol)
- Heavy metal chelation
- Mucus thinning (respiratory)
- OCD/addiction support
- Anti-inflammatory
Possible side effects
- GI discomfort
- Sulfur smell/taste
- Nausea
- Rare: histamine liberation
- May deplete zinc/copper
Research
- NAC and liver protection (2021): Standard of care for acetaminophen overdose; 1200mg/day reduced ALT elevations by 50% in NAFLD patients over 12 weeks.
- NAC and glutamate modulation (2022): Meta-analysis showed NAC (2400mg/day) reduced OCD symptom severity by 30% and substance craving scores by 40% as adjunctive therapy.
Compare NAC
Community discussions about NAC
- Trying GlyNAC for a month – any notes on energy and skin? - 5 comments
- First week on survodutide 0.6 mg – appetite changes and mild nausea - 4 comments
- oxandrolone bloodwork, hdl tanked at 10mg daily - 3 comments
- MK-677 vs CJC/Ipa combo for sleep quality and hunger management - 4 comments
- Feedback on Pentosan + Boswellia + Diclofenac gel stack for joint recovery - 3 comments
- Ask the community about NAC
Research and educational reference only. Not medical advice.