Quercetin (Quercetin (Flavonoid Senolytic))
A plant flavonoid best known in biohacking as half of the classic "fisetin/dasatinib + quercetin" senolytic protocols. Also used for its antioxidant, anti-inflammatory, antihistamine, and immune-supportive properties.
How it works
Selectively induces apoptosis in senescent cells by inhibiting pro-survival (SCAP/BCL) pathways, especially when paired with dasatinib. Also scavenges free radicals, inhibits mast-cell histamine release, and modulates NF-kB inflammatory signaling.
Key facts
- Molecular weight: 302.24 Da
- Half-life: ~11-28 hours
- Bioavailability: Low; improved by phytosome/bromelain formulations
- Storage: Room temperature, protect from light and moisture.
Dosing overview
- Typical dose: 500-1000 mg per day (daily) or high-dose pulsed (senolytic)
- Frequency: Daily or intermittent
- Duration: Ongoing or pulsed
- Route: Oral capsule
Protocol notes
- General use: 500-1000 mg/day, often with vitamin C or bromelain for absorption.
- Senolytic protocols use high pulsed doses (e.g. ~1000-1500 mg) for 2-3 consecutive days, then a multi-week break.
- Phytosome forms substantially increase absorption at lower doses.
Reported benefits
- Senolytic (clears senescent cells)
- Antioxidant and anti-inflammatory
- Natural antihistamine
- Cardiovascular support
- Immune modulation
- Synergy with fisetin/dasatinib
Possible side effects
- GI upset at high doses
- Headache
- Tingling (very high doses)
- Drug interactions (CYP inhibition)
- Kidney caution at extreme doses
Research
- Dasatinib plus quercetin clears senescent cells (2019): The D+Q senolytic combination reduced senescent cell burden and improved physical function in a first-in-human pilot.
- Quercetin anti-inflammatory effects (2020): Reduced inflammatory cytokines and oxidative stress markers across multiple human and animal studies.
Compare Quercetin
Research and educational reference only. Not medical advice.