Progesterone vs Testosterone Cypionate
A side-by-side research comparison of Progesterone and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Progesterone | Testosterone Cypionate |
|---|---|---|
| Full name | Micronized Progesterone (Prometrium) | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved | FDA Approved (Schedule III) |
| Mechanism | Agonizes progesterone receptors and GABA-A receptors (via allopregnanolone metabolite). Inhibits 5-alpha reductase, opposes estrogen proliferative effects, and promotes myelination in neural tissue. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | 314.46 Da | 412.61 Da |
| Half-life | ~16-18 hours (oral micronized) | ~8 days |
| Bioavailability | ~10% oral (first-pass); ~100% topical/vaginal | ~100% (intramuscular) |
| Typical dose | 100-200 mg oral or 20-40 mg topical | 100-200 mg |
| Frequency | Nightly (oral) or daily (topical) | Weekly or split biweekly |
| Route | Oral capsule, topical cream, or vaginal | Intramuscular or subcutaneous injection |
Progesterone reported benefits
- Enhanced deep sleep (GABA modulation)
- Neuroprotection
- Estrogen opposition
- Reduced anxiety
- DHT reduction (5AR inhibition)
- Cardiovascular protection
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
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Research and educational reference only. Not medical advice.