DHEA vs Progesterone
A side-by-side research comparison of DHEA and Progesterone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Progesterone |
|---|---|---|
| Full name | Dehydroepiandrosterone | Micronized Progesterone (Prometrium) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | FDA Approved |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Agonizes progesterone receptors and GABA-A receptors (via allopregnanolone metabolite). Inhibits 5-alpha reductase, opposes estrogen proliferative effects, and promotes myelination in neural tissue. |
| Molecular weight | 288.42 Da | 314.46 Da |
| Half-life | 15-38 hours | ~16-18 hours (oral micronized) |
| Bioavailability | ~100% oral | ~10% oral (first-pass); ~100% topical/vaginal |
| Typical dose | 25-100 mg | 100-200 mg oral or 20-40 mg topical |
| Frequency | Daily (morning) | Nightly (oral) or daily (topical) |
| Route | Oral capsule or topical cream | Oral capsule, topical cream, or vaginal |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Progesterone reported benefits
- Enhanced deep sleep (GABA modulation)
- Neuroprotection
- Estrogen opposition
- Reduced anxiety
- DHT reduction (5AR inhibition)
- Cardiovascular protection
Related comparisons
Research and educational reference only. Not medical advice.