Semax vs Synapsin
A side-by-side research comparison of Semax and Synapsin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Semax | Synapsin |
|---|---|---|
| Full name | Semax (ACTH 4-10 analog) | Synapsin Nasal Spray (RG3 + NAD+ + Methylcobalamin) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Research compound | Compounded medication |
| Mechanism | Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity. | Rg3 reduces neuroinflammation and protects neurons. NAD+ supports mitochondrial function and sirtuin activation in brain cells. Methylcobalamin provides methylation support and myelin repair. Nasal route bypasses BBB for direct CNS delivery. |
| Molecular weight | 813.9 Da | Combination compound |
| Half-life | 3-5 min (systemic) / extended (intranasal) | Variable (nasal depot effect) |
| Bioavailability | Moderate (intranasal) | ~60-80% nasal (direct CNS access) |
| Typical dose | 200-600 mcg per dose | 1-2 sprays per nostril |
| Frequency | 2-3x daily | 1-2x daily |
| Route | Intranasal drops/spray | Intranasal spray |
Semax reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Synapsin reported benefits
- Improved mental clarity
- Reduced brain fog
- Neuroprotection
- Enhanced focus
- Nerve repair support
- Anti-neuroinflammatory
Related comparisons
Research and educational reference only. Not medical advice.