Semax (Semax (ACTH 4-10 analog))
A synthetic peptide from ACTH(4-10) with Pro-Gly-Pro stabilization. Approved in Russia for stroke and cognitive disorders. Enhances attention, memory, and neuroplasticity.
How it works
Activates MC3/4R, increases BDNF and NGF, modulates dopamine/serotonin, enhances neuronal survival via TrkB, and promotes CREB-mediated neuroplasticity.
Key facts
- Molecular weight: 813.9 Da
- Half-life: 3-5 min (systemic) / extended (intranasal)
- Bioavailability: Moderate (intranasal)
- Storage: Solution: 2-8°C. Use within 30 days of opening.
Dosing overview
- Typical dose: 200-600 mcg per dose
- Frequency: 2-3x daily
- Duration: 2-4 week courses
- Route: Intranasal drops/spray
Protocol notes
- Intranasal, split into 2-3 doses across the day.
- The N-acetyl (NA-Semax) version is more potent/longer-acting, so doses run a bit lower.
- Often paired with Selank.
Reported benefits
- Enhanced attention/focus
- Memory improvement
- Neuroprotection (stroke)
- BDNF/NGF upregulation
- Improved learning
- Optic nerve support
Possible side effects
- Nasal irritation
- Headache
- Hair loss (very high doses, rare)
- Irritability
Research
- Semax neuroprotection in acute ischemic stroke (2021): Intranasal semax within 6h of stroke reduced infarct volume by 25% and improved outcomes at 30 days.
- Cognitive enhancement by semax in healthy volunteers (2020): Improved working memory by 20% and selective attention by 30% in 14-day crossover study.
Compare Semax
Community discussions about Semax
- Thoughts on na semax and bdnf levels - 4 comments
- My experience trying a Semax and Selank combo for study stress - 4 comments
- Trying Adamax nasal spray for focus – my two‑week log - 7 comments
- My 2‑week run with Adamax – focus, mood and a few side notes - 4 comments
- Semax vs Selank for focus without the jitters? - 8 comments
- Ask the community about Semax
Research and educational reference only. Not medical advice.