TB-500 vs TB4-Frag (TBF)
A side-by-side research comparison of TB-500 and TB4-Frag (TBF) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | TB-500 | TB4-Frag (TBF) |
|---|---|---|
| Full name | Thymosin Beta-4 (Synthetic) | Thymosin Beta-4 Fragment |
| Category | Healing & Recovery | Healing & Recovery |
| Status | Research compound | Research compound |
| Mechanism | Upregulates actin production to promote cell migration and proliferation, enhances angiogenesis, and reduces pro-inflammatory cytokines. | Retains the actin-sequestering motif of full TB-4, promoting cell migration, angiogenesis, and reduction of inflammation at injury sites. The shorter sequence may offer improved bioavailability and targeted tissue penetration. |
| Molecular weight | 4921 Da | ~1,200-1,800 Da (fragment) |
| Half-life | ~6 hours | ~2-4 hours |
| Bioavailability | ~95% via subcutaneous injection | High subcutaneous absorption |
| Typical dose | 2-5 mg per dose | 200-750 mcg per dose |
| Frequency | Loading: 2x/week · Maintenance: 1x/week | Daily or every other day |
| Route | Subcutaneous injection | Subcutaneous injection |
TB-500 reported benefits
- Enhanced wound healing
- Reduced inflammation
- Improved flexibility
- Cardiac tissue repair
- Hair regrowth support
TB4-Frag (TBF) reported benefits
- Wound and tissue healing
- Reduced inflammation
- Potential improved tissue penetration vs full TB-4
- Support for tendon and muscle repair
- Angiogenesis promotion
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Research and educational reference only. Not medical advice.