TB4-Frag (TBF) (Thymosin Beta-4 Fragment)
An active fragment of Thymosin Beta-4 (TB-500) containing the key actin-binding domain responsible for tissue repair signaling. Smaller molecular size may improve tissue penetration while retaining the healing properties of the full-length peptide.
How it works
Retains the actin-sequestering motif of full TB-4, promoting cell migration, angiogenesis, and reduction of inflammation at injury sites. The shorter sequence may offer improved bioavailability and targeted tissue penetration.
Key facts
- Molecular weight: ~1,200-1,800 Da (fragment)
- Half-life: ~2-4 hours
- Bioavailability: High subcutaneous absorption
- Storage: Lyophilized: room temperature. Reconstituted: refrigerate 2-8C.
Dosing overview
- Typical dose: 200-750 mcg per dose
- Frequency: Daily or every other day
- Duration: 4-8 weeks
- Route: Subcutaneous injection
Protocol notes
- Loading: 500-750 mcg daily for 2 weeks.
- Maintenance: 200-500 mcg every other day for 4-6 weeks.
- Often used for localized injury protocols.
Reported benefits
- Wound and tissue healing
- Reduced inflammation
- Potential improved tissue penetration vs full TB-4
- Support for tendon and muscle repair
- Angiogenesis promotion
Possible side effects
- Injection site irritation
- Mild headache (rare)
- Fatigue (transient)
Research
- Active domain mapping of Thymosin Beta-4 (2018): The central actin-binding domain (Ac-SDKP and LKKTET motifs) retains the majority of TB4 healing activity.
Compare TB4-Frag (TBF)
Research and educational reference only. Not medical advice.