5-Amino-1MQ Research Guide

Full name: 5-Amino-1-Methylquinolinium (NNMT Inhibitor)

A small molecule inhibitor of NNMT, an enzyme upregulated in obesity. By blocking NNMT, it increases NAD+ and SAM availability, boosting cellular energy metabolism.

How 5-Amino-1MQ Works

Inhibits NNMT enzyme, preventing methylation and degradation of nicotinamide. Increases intracellular NAD+ pools, activates sirtuins, and reduces fat cell size without affecting food intake.

Dosing Protocol

• Typical dose: 50-100 mg
• Frequency: 1-2x daily
• Duration: 8-12 weeks
• Route: Oral (capsule)

Reported Benefits

• Increased cellular energy metabolism
• Reduced fat cell size
• Elevated NAD+ levels
• Does not suppress appetite
• Improved muscle stem cell function
• Oral convenience

Potential Side Effects

• Mild GI discomfort
• Headache (rare)
• Insomnia if taken late

Research Citations

1. NNMT inhibition with 5-amino-1MQ reduces adiposity in DIO mice (2021) - 5-amino-1MQ reduced body weight by 7% and visceral fat by 30% without affecting food intake.
2. NNMT as therapeutic target for obesity (2022) - NNMT inhibition increased NAD+ by 40%, enhanced sirtuin activity, and reduced adipocyte hypertrophy.

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