ResearchSafe

5-Amino-1MQ (5-Amino-1-Methylquinolinium (NNMT Inhibitor))

Category: Weight Management. Status: Research compound.

A small molecule inhibitor of NNMT, an enzyme upregulated in obesity. By blocking NNMT, it increases NAD+ and SAM availability, boosting cellular energy metabolism.

How it works

Inhibits NNMT enzyme, preventing methylation and degradation of nicotinamide. Increases intracellular NAD+ pools, activates sirtuins, and reduces fat cell size without affecting food intake.

Key facts

  • Molecular weight: 173.2 Da
  • Half-life: 8-12 hours
  • Bioavailability: High (oral)
  • Storage: Room temperature, protected from light and moisture.

Dosing overview

  • Typical dose: 50-100 mg
  • Frequency: 1-2x daily
  • Duration: 8-12 weeks
  • Route: Oral (capsule)

Reported benefits

  • Increased cellular energy metabolism
  • Reduced fat cell size
  • Elevated NAD+ levels
  • Does not suppress appetite
  • Improved muscle stem cell function
  • Oral convenience

Possible side effects

  • Mild GI discomfort
  • Headache (rare)
  • Insomnia if taken late

Research

  • NNMT inhibition with 5-amino-1MQ reduces adiposity in DIO mice (2021): 5-amino-1MQ reduced body weight by 7% and visceral fat by 30% without affecting food intake.
  • NNMT as therapeutic target for obesity (2022): NNMT inhibition increased NAD+ by 40%, enhanced sirtuin activity, and reduced adipocyte hypertrophy.

Community reviews of 5-Amino-1MQ

Rated 4.6 out of 5 from 12 community reviews by ResearchSafe members.

  • steady_state_stan rated it 5/5 - Worth adding to the protocol: 5-Amino-1MQ has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
  • data_driven_dan rated it 5/5 - Noticed clear benefits within weeks: Added 5-Amino-1MQ to my protocol about 1 month ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
  • bloodwork_brett rated it 5/5 - Genuinely effective after 2 months: Been using 5-Amino-1MQ for about 2 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
  • optimizer_jenna rated it 5/5 - Finally fit into my classroom clothes again: As a 39-year-old teacher in Germany, I tried 5-Amino-1MQ after I got sick of feeling stuck and sluggish at 82 kg. Over about 3 months, my waist changed first, then the scale followed. I lost 14 kg. For me it really helped, tbh.
  • recovery_midwest rated it 5/5 - six months, smaller waist, less grinding in the mirror: i’m a grad student on the east coast, and between sitting too much and trying to keep my 50s body from turning into a puddle, i wanted something that felt more metabolic than appetite based. the first 2 weeks were subtle, then around week 4 my waist started loosening up and the scale moved without me white-knuckling food. over 6 months i dropped about 51 lbs, and for me it kept feeling steady, just quieter and cleaner than i expected 🔬
  • optimizer_kayla rated it 4/5 - Helpful for a cut, but my sleep got a bit odd: I tried 5-Amino-1MQ for about 4 weeks while I was trying to tidy up my midsection a bit, mostly because long clinic days and odd meal timings in India do not exactly make fat loss graceful. For me, it seemed to help with steady energy and I did notice my waist felt a touch tighter by the end. The annoying part was sleep. Not bad, just lighter, with a slightly “wired” feeling some evenings. Could have been timing, could have been the compound. I still rate it 4 stars because the effect felt useful overall, but I would not ignore that sleep thing, no?

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Community discussions about 5-Amino-1MQ

Research and educational reference only. Not medical advice.