5-Amino-1MQ (5-Amino-1-Methylquinolinium (NNMT Inhibitor))
A small molecule inhibitor of NNMT, an enzyme upregulated in obesity. By blocking NNMT, it increases NAD+ and SAM availability, boosting cellular energy metabolism.
How it works
Inhibits NNMT enzyme, preventing methylation and degradation of nicotinamide. Increases intracellular NAD+ pools, activates sirtuins, and reduces fat cell size without affecting food intake.
Key facts
- Molecular weight: 173.2 Da
- Half-life: 8-12 hours
- Bioavailability: High (oral)
- Storage: Room temperature, protected from light and moisture.
Dosing overview
- Typical dose: 50-100 mg
- Frequency: 1-2x daily
- Duration: 8-12 weeks
- Route: Oral (capsule)
Reported benefits
- Increased cellular energy metabolism
- Reduced fat cell size
- Elevated NAD+ levels
- Does not suppress appetite
- Improved muscle stem cell function
- Oral convenience
Possible side effects
- Mild GI discomfort
- Headache (rare)
- Insomnia if taken late
Research
- NNMT inhibition with 5-amino-1MQ reduces adiposity in DIO mice (2021): 5-amino-1MQ reduced body weight by 7% and visceral fat by 30% without affecting food intake.
- NNMT as therapeutic target for obesity (2022): NNMT inhibition increased NAD+ by 40%, enhanced sirtuin activity, and reduced adipocyte hypertrophy.
Compare 5-Amino-1MQ
Community discussions about 5-Amino-1MQ
- Adding 5-Amino-1MQ to semaglutide to fight a plateau? - 0 comments
- Trying 5-Amino-1MQ with my semaglutide – weight and waist changes - 4 comments
- Semaglutide plateau at month 4, thinking about adding 5-Amino-1MQ - 4 comments
- Noticed mild headache and sleep trouble with 5-Amino-1MQ wondering if timing matters - 4 comments
- Confused about starting semaglutide and the Apollo stack - 3 comments
- Ask the community about 5-Amino-1MQ
Research and educational reference only. Not medical advice.