ACE-031 (ACE-031 (Soluble ActRIIB-Fc Fusion))
A soluble ActRIIB-Fc fusion acting as ligand trap for myostatin, activin, and GDF-11. Removes multiple negative regulators of muscle growth simultaneously.
How it works
Decoy receptor sequestering TGF-B ligands (myostatin, activin, GDF-11) in bloodstream, preventing cell-surface ActRIIB binding and removing multiple anabolic brakes.
Key facts
- Molecular weight: ~90,000 Da
- Half-life: 10-14 days
- Bioavailability: High (SubQ)
- Storage: Refrigerated 2-8°C. Do not freeze.
Dosing overview
- Typical dose: 0.3-3 mg/kg
- Frequency: Every 2-4 weeks
- Duration: 12-24 weeks
- Route: Subcutaneous
Reported benefits
- Multi-ligand pathway inhibition
- Lean mass increase
- Bone density increase
- Infrequent dosing
- Functional strength improvement
Possible side effects
- Epistaxis
- Gum bleeding
- Telangiectasia
- Vascular effects
- Development halted for DMD
Research
- ACE-031 in Duchenne muscular dystrophy (2019): Increased lean body mass by 5% in 12 weeks; halted due to bleeding/vascular events.
- ActRIIB decoy receptors for cancer cachexia (2021): Reversed cancer muscle wasting by 30% and improved grip strength without tumor effects.
Community reviews of ACE-031
- dose_math_derek rated it 5/5 - Noticed clear benefits within weeks: Added ACE-031 to my protocol about 6 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- needle_notes_nate rated it 5/5 - Worth adding to the protocol: ACE-031 has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- careful_claire rated it 5/5 - Solid compound with real results: Been using ACE-031 for about 1 month and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- loading_phase_lucy rated it 5/5 - Genuinely effective after 6 months: Been using ACE-031 for about 6 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- paddles_nomad rated it 4/5 - Big leg fullness, but it came with a weird price: The main thing I noticed was my legs looked and felt fuller in the squat rack after about 12 weeks, which was pretty damn cool for me as a Midwest powerlifter pushing into my 50s. Arms and recovery seemed a bit better too, but I also felt some joint stiffness, so that part kept it from being a clean win.
- wes_cycles rated it 5/5 - Finally filled out after years of flat training logs: I tried ACE-031 after a long stretch where my lifts in the gym and my bodyweight in Singapore were just stuck, even though I was eating properly and training hard as a CPT. Over about 6 months, my legs and upper back started to feel thicker, and my scale trend moved in a way I had not seen in ages. Could just be my own response, but the change was steady enough that my notes looked pretty clear, lah.
Compare ACE-031
Research and educational reference only. Not medical advice.