Alpha-Lipoic Acid (ALA) (R-Alpha-Lipoic Acid Injectable)
A powerful antioxidant that works in both water and fat-soluble environments. Injectable ALA from telemedicine clinics provides superior bioavailability for neuropathy, metabolic support, and detoxification.
How it works
Regenerates glutathione, vitamin C, and vitamin E. Chelates heavy metals. Acts as cofactor for mitochondrial enzyme complexes. Activates Nrf2 pathway for endogenous antioxidant production.
Key facts
- Molecular weight: 206.33 Da
- Half-life: ~30 minutes (oral); longer IM
- Bioavailability: ~30% oral; ~100% injectable
- Storage: Protect from light and heat.
Dosing overview
- Typical dose: 200-600 mg
- Frequency: 1-3x per week (injectable)
- Duration: Ongoing or cycled
- Route: IV/IM injection or oral capsule
Protocol notes
- Injectable courses commonly run ~300-600 mg per dose, a few times weekly (e.g. for neuropathy).
- Oral dosing needs the R-form on an empty stomach for best absorption (~600 mg/day split).
- Use the R-isomer (R-ALA) where possible - it is the biologically active form.
Reported benefits
- Universal antioxidant
- Neuropathy relief
- Heavy metal chelation
- Blood sugar regulation
- Glutathione recycling
- Liver protection
Possible side effects
- Mild nausea
- Skin rash (rare)
- Hypoglycemia risk
- Body odor changes
- GI upset
Research
- ALA in diabetic neuropathy (2021): IV ALA improved neuropathy symptom scores by 50% over 3-week course in randomized controlled trial.
Compare Alpha-Lipoic Acid (ALA)
Research and educational reference only. Not medical advice.