Alpha-Lipoic Acid (ALA) vs Epithalon
A side-by-side research comparison of Alpha-Lipoic Acid (ALA) and Epithalon across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Alpha-Lipoic Acid (ALA) | Epithalon |
|---|---|---|
| Full name | R-Alpha-Lipoic Acid Injectable | Epithalon (Epitalon / Epithalone) |
| Category | Anti-Aging | Anti-Aging |
| Status | Supplement / Compounded injectable | Research compound |
| Mechanism | Regenerates glutathione, vitamin C, and vitamin E. Chelates heavy metals. Acts as cofactor for mitochondrial enzyme complexes. Activates Nrf2 pathway for endogenous antioxidant production. | Activates telomerase reverse transcriptase (hTERT) expression for telomere maintenance. Also normalizes circadian rhythm via melatonin regulation and modulates antioxidant enzymes. |
| Molecular weight | 206.33 Da | 390.4 Da |
| Half-life | ~30 minutes (oral); longer IM | 3-4 hours |
| Bioavailability | ~30% oral; ~100% injectable | High (SubQ) |
| Typical dose | 200-600 mg | 5-10 mg |
| Frequency | 1-3x per week (injectable) | Daily for 10-20 days |
| Route | IV/IM injection or oral capsule | Subcutaneous injection |
Alpha-Lipoic Acid (ALA) reported benefits
- Universal antioxidant
- Neuropathy relief
- Heavy metal chelation
- Blood sugar regulation
- Glutathione recycling
- Liver protection
Epithalon reported benefits
- Telomerase activation
- Telomere lengthening
- Melatonin normalization
- Improved sleep patterns
- Antioxidant enzyme upregulation
- Potential lifespan extension
Related comparisons
Research and educational reference only. Not medical advice.