Apollo Stack (Apollo (Semaglutide + 5-Amino-1MQ + MOTS-c + Tesamorelin))
An aggressive fat loss and metabolic optimization stack. Combines GLP-1 receptor agonism for appetite suppression, NNMT inhibition for cellular metabolism, mitochondrial optimization, and targeted visceral fat reduction for maximum body recomposition.
How it works
Semaglutide activates GLP-1 receptors for appetite/glucose control. 5-Amino-1MQ inhibits NNMT to boost NAD+ and cellular energy. MOTS-c activates AMPK like exercise. Tesamorelin specifically targets visceral fat through GH-mediated lipolysis.
Key facts
- Molecular weight: Multiple compounds
- Half-life: Semaglutide: ~7 days, 5A1MQ: ~6h, MOTS-c: ~4h, Tesamorelin: ~30min
- Bioavailability: Variable by component
- Storage: Semaglutide: 2-8°C. Others: lyophilized at -20°C.
Dosing overview
- Typical dose: Sema 0.25-2.4mg/wk + 5A1MQ 100mg 2x/day + MOTS-c 10mg 3x/wk + Tesa 2mg/day
- Frequency: Variable by component
- Duration: 16-24 weeks
- Route: SC injection + Oral
Protocol notes
- Semaglutide: start 0.25 mg once weekly and titrate up every ~4 weeks toward 2.4 mg as tolerated.
- 5-Amino-1MQ: 100 mg orally twice daily.
- MOTS-c: ~10 mg subcutaneously 3x per week.
- Tesamorelin: ~2 mg subcutaneously nightly to target visceral fat.
- Pair with resistance training and adequate protein to preserve muscle during aggressive fat loss.
Reported benefits
- Dramatic fat loss
- Visceral fat reduction
- Metabolic rate increase
- Appetite control
- Improved insulin sensitivity
- Cellular energy boost
Possible side effects
- Nausea (semaglutide)
- Reduced appetite
- Injection site reactions
- Transient GI discomfort
- Potential muscle loss without exercise
Research
- Multi-pathway metabolic intervention for obesity (2023): Combination metabolic protocols achieved 18-22% body weight loss with improved lean mass preservation vs GLP-1 monotherapy.
- MOTS-c as exercise mimetic alongside GLP-1 therapy (2022): MOTS-c addition preserved muscle mass during aggressive weight loss, addressing a key limitation of GLP-1 drugs.
Compare Apollo Stack
Community discussions about Apollo Stack
- Adding 5-Amino-1MQ to semaglutide to fight a plateau? - 0 comments
- My first 4‑week run with the Apollo stack – dosing tweaks and what I felt - 4 comments
- My Apollo Stack Run: Appetite, Nausea & A outspoken Body Fat Drop - 6 comments
- Semaglutide alongside a healing stack, anyone managed appetite suppression + recovery eating? - 7 comments
- Confused about starting semaglutide and the Apollo stack - 3 comments
- Ask the community about Apollo Stack
Research and educational reference only. Not medical advice.