Canagliflozin (Canagliflozin (SGLT2 Inhibitor))
An FDA-approved SGLT2 inhibitor for type 2 diabetes that gained longevity attention after the ITP showed it extended male mouse lifespan. Biohackers use it for glucose control, cardiovascular/kidney protection, and its caloric-loss "metabolic offloading" effect.
How it works
Blocks the sodium-glucose cotransporter 2 in the kidney, causing excess glucose to be excreted in urine. This lowers blood glucose independent of insulin, reduces blood pressure and weight, and produces cardio-renal protective effects.
Key facts
- Molecular weight: 444.52 Da
- Half-life: ~11-13 hours
- Bioavailability: ~65% oral
- Storage: Room temperature, protect from moisture.
Dosing overview
- Typical dose: 100-300 mg per day
- Frequency: Once daily
- Duration: Ongoing
- Route: Oral tablet
Protocol notes
- Standard start is 100 mg once daily before the first meal.
- May be increased to 300 mg daily with clinician guidance.
- Adequate hydration is important due to glucose-driven diuresis.
Reported benefits
- Insulin-independent glucose lowering
- Cardiovascular protection
- Kidney protection
- Blood pressure reduction
- Weight loss
- Longevity signal (ITP data)
Possible side effects
- Genital yeast/urinary infections
- Dehydration/dizziness
- Increased urination
- Rare euglycemic DKA
- Electrolyte shifts
Research
- Canagliflozin extends male mouse lifespan (ITP) (2020): Increased median male lifespan by ~14% in the NIA Interventions Testing Program.
- CANVAS cardiovascular outcomes (2017): Reduced major adverse cardiovascular events and progression of kidney disease in type 2 diabetics.
Community reviews of Canagliflozin
- research_marcus rated it 5/5 - Genuinely effective after 3 months: Been using Canagliflozin for about 3 months and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- protocol_pete rated it 5/5 - Solid compound with real results: Been using Canagliflozin for about 2 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- deep_science_dee rated it 4/5 - Worth adding to the protocol: Canagliflozin has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- deep_science_dee rated it 5/5 - Noticed clear benefits within weeks: Added Canagliflozin to my protocol about 2 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
Compare Canagliflozin
Community discussions about Canagliflozin
- Canagliflozin and dehydration – my experience and hydration tips - 10 comments
- Canagliflozin making me go to the bathroom every 2 hours and feel light‑headed - 3 comments
- Ask the community about Canagliflozin
Research and educational reference only. Not medical advice.