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Collagen Peptides (Hydrolyzed Collagen Peptides (Types I, II, III))

Category: Skin & Anti-Aging. Status: Dietary supplement (GRAS).

Bioactive peptide fragments from enzymatic hydrolysis of collagen protein. Orally bioavailable and stimulate endogenous collagen synthesis in skin, joints, and bones.

How it works

Absorbed as di/tripeptides (Pro-Hyp, Hyp-Gly), accumulate in skin and signal fibroblasts to increase collagen, hyaluronic acid, and elastin production.

Key facts

  • Molecular weight: 2,000-5,000 Da (average)
  • Half-life: 4-6 hours (plasma peptides)
  • Bioavailability: High (oral, >90% absorption)
  • Storage: Room temperature, dry, sealed container.

Dosing overview

  • Typical dose: 5-15 g
  • Frequency: Once daily
  • Duration: 8-12 weeks minimum
  • Route: Oral (powder/capsule)

Reported benefits

  • Improved skin elasticity/hydration
  • Reduced wrinkle depth
  • Joint pain reduction
  • Nail/hair strength
  • Bone density support

Possible side effects

  • Mild bloating (initial)
  • Unpleasant taste (some)
  • Rare allergic reaction (marine)

Research

  • Oral collagen peptides improve skin elasticity: meta-analysis (2023): Meta-analysis of 19 RCTs confirmed improved hydration (25%) and elasticity (20%) vs placebo.
  • Specific collagen peptides improve joint function in athletes (2021): 5g daily reduced activity-related joint pain by 38% over 12 weeks.

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Research and educational reference only. Not medical advice.