Hexarelin (Hexarelin (Examorelin))
The most potent synthetic GHRP with unique cardioprotective properties independent of GH release through cardiac CD36 receptor binding.
How it works
Potent GHSR-1a agonist producing maximal pituitary GH output. Additionally binds cardiac CD36, providing cardioprotection through anti-apoptotic mechanisms independent of GH.
Key facts
- Molecular weight: 887 Da
- Half-life: 1-2 hours
- Bioavailability: High (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C.
Dosing overview
- Typical dose: 100-200 mcg
- Frequency: 2-3x daily
- Duration: 4-8 weeks (then break)
- Route: Subcutaneous
Reported benefits
- Strongest GH release
- Cardioprotective effects
- Recovery acceleration
- Anti-fibrotic (cardiac)
- Neuroprotective potential
Possible side effects
- Cortisol/prolactin increase
- Rapid desensitization
- Water retention
- Flushing
Research
- Cardioprotective mechanisms of hexarelin via CD36 (2021): Hexarelin reduced infarct size by 40% independent of GH via anti-apoptotic pathways.
- Hexarelin desensitization kinetics (2019): GH response decreased by 50% after 14 days; full recovery after 4-week washout.
Compare Hexarelin
Community discussions about Hexarelin
- Hexarelin vs Ipamorelin for night shift recovery – what’s your take? - 10 comments
- Noticing some weirdness with hexarelin and my cortisol levels - 0 comments
- Hexarelin + Ipamorelin stack – any notes on GH pulse and heart feel? - 3 comments
- Hexarelin cortisol and prolactin spike, anyone else notice this - 6 comments
- Hexarelin water retention and flushing – how to tame it? - 5 comments
- Ask the community about Hexarelin
Research and educational reference only. Not medical advice.