ResearchSafe

HGH Fragment 176-191 (Human Growth Hormone Fragment 176-191)

Category: Weight Management. Status: Research compound.

The lipolytic fragment of human growth hormone (amino acids 176-191). Retains fat-burning properties of HGH without growth-promoting or diabetogenic effects.

How it works

Mimics lipolytic action of HGH by stimulating beta-3 adrenergic receptors on adipocytes, increasing cyclic AMP and hormone-sensitive lipase activity. Does not affect IGF-1.

Key facts

  • Molecular weight: 1,817 Da
  • Half-life: 3-4 hours
  • Bioavailability: High (SubQ)
  • Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 21 days.

Dosing overview

  • Typical dose: 250-500 mcg
  • Frequency: 1-2x daily
  • Duration: 8-12 weeks
  • Route: Subcutaneous

Reported benefits

  • Targeted fat loss
  • No IGF-1 elevation
  • No glucose impairment
  • No bone/organ growth effects
  • Improved body composition

Possible side effects

  • Injection site irritation
  • Mild headache
  • Slight drowsiness

Research

  • Lipolytic effects of GH fragment 176-191 in obese mice (2018): Produced significant fat mass reduction without affecting lean mass, glucose, or IGF-1 levels.
  • Fat metabolism modulation by GH peptide fragments (2020): 176-191 fragment stimulated lipolysis at rates comparable to full hGH while showing no diabetogenic potential.

Compare HGH Fragment 176-191

Community discussions about HGH Fragment 176-191

Research and educational reference only. Not medical advice.