Kisspeptin-10 (Kisspeptin-10 (Metastin 45-54))
The shortest bioactive kisspeptin fragment, a master regulator of reproduction. Activates GnRH neurons to stimulate the HPG axis, increasing LH, FSH, and sex hormones.
How it works
Binds KISS1R on GnRH neurons, stimulating GnRH pulsatile release for LH/FSH secretion. Also enhances limbic sexual arousal circuits.
Key facts
- Molecular weight: 1,302 Da
- Half-life: 4-6 min (IV) / 20-30 min (SubQ)
- Bioavailability: High (IV/SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: use immediately.
Dosing overview
- Typical dose: 1-10 nmol/kg
- Frequency: Single dose or daily
- Duration: Acute or short-course
- Route: IV or Subcutaneous
Reported benefits
- Stimulates GnRH naturally
- Increases LH and testosterone
- Enhances sexual arousal (fMRI data)
- Potential fertility aid
- HPG axis diagnostic tool
Possible side effects
- Hot flashes
- Headache
- Transient LH surge
- Nausea (rare)
Research
- Kisspeptin-10 and sexual brain processing in men (2022): Increased limbic brain activity to sexual stimuli by 40% and improved penile tumescence.
- Kisspeptin restores LH pulsatility in hypothalamic amenorrhea (2021): Restored LH pulses in women with functional HA, suggesting fertility therapeutic potential.
Compare Kisspeptin-10
Community discussions about Kisspeptin-10
- Looking for feedback on my NR + Kisspeptin-10 + Gonadorelin stack dosing and timing - 5 comments
- Kisspeptin-10 injections left me with a hot mess at the injection sites - 4 comments
- 🔥🔥📢📢🌶️🌶️ Do you finding a reliable Weight Loss & Metabolic Peptides vendor?Come on! - 0 comments
- Kisspeptin-10 thoughts after reading the profile - 6 comments
- Feedback on my NR + Kisspeptin-10 + Gonadorelin stack – doses and timing - 6 comments
- Ask the community about Kisspeptin-10
Research and educational reference only. Not medical advice.