Matrixyl (Matrixyl (Palmitoyl Pentapeptide-4 / Pal-KTTKS))
A lipopeptide of palmitic acid linked to pentapeptide KTTKS. One of the most researched anti-aging cosmeceutical peptides, stimulating collagen and fibronectin.
How it works
Signals through TGF-B pathway to stimulate fibroblast production of collagen I, III, IV, fibronectin, and hyaluronic acid. Palmitoyl chain enhances penetration.
Key facts
- Molecular weight: 802.1 Da
- Half-life: 6-12 hours (topical depot)
- Bioavailability: Moderate (topical)
- Storage: Room temperature, protected from direct sunlight.
Dosing overview
- Typical dose: 2-8% in serum/cream
- Frequency: 1-2x daily
- Duration: 8-12 weeks for visible results
- Route: Topical
Reported benefits
- Stimulates collagen I, III, IV
- Reduces wrinkle depth up to 45%
- Increases skin thickness
- Improves firmness
- Enhances hydration
Possible side effects
- Rarely irritating
- Possible mild tingling
Research
- Topical palmitoyl pentapeptide-4 reduces wrinkle depth (2020): Reduced wrinkle depth by 36% and improved roughness by 18% in 12-week double-blind study.
- Collagen stimulation by KTTKS in human fibroblasts (2019): Increased type I procollagen by 117% and fibronectin by 200% in cultured fibroblasts.
Compare Matrixyl
Community discussions about Matrixyl
- Confused about Matrixyl vs Palmitoyl Tetrapeptide-7 for skin stuff - 4 comments
- Trying Matrixyl serum for a month – any changes in skin texture? - 6 comments
- Anyone notice real changes with Matrixyl for skin aging? Beginner's report - 4 comments
- Trying Matrixyl 3000 with low‑dose rapamycin – any skin changes? - 4 comments
- Testing a Triple Matrixyl Routine: Pal‑GHK, Pal‑GQPR, and Pal‑Penta – Need Feedback - 4 comments
- Ask the community about Matrixyl
Research and educational reference only. Not medical advice.