MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
A mitochondria-derived peptide that acts as an exercise mimetic, improving metabolic homeostasis, insulin sensitivity, and fat oxidation. Levels decline significantly with age.
How it works
Activates AMPK pathway, enhances mitochondrial metabolism, improves insulin sensitivity by increasing GLUT4 translocation, and promotes fatty acid oxidation.
Key facts
- Molecular weight: 2,175 Da
- Half-life: 4-8 hours
- Bioavailability: Moderate (SubQ)
- Storage: Lyophilized: -20°C. Reconstituted: 2-8°C for 14 days.
Dosing overview
- Typical dose: 5-10 mg
- Frequency: 3-5x per week
- Duration: 8-12 weeks
- Route: Subcutaneous injection
Protocol notes
- Most run 5-10 mg per dose, 3-5x weekly (not usually daily).
- Many time doses around training to leverage the AMPK/metabolic effect.
Reported benefits
- Exercise mimetic effects
- Improved insulin sensitivity
- Enhanced fat oxidation
- Metabolic homeostasis
- Anti-aging metabolic benefits
- AMPK activation
Possible side effects
- Injection site reactions
- Mild hypoglycemia (with exercise)
- Fatigue initially
- Flushing (rare)
Research
- MOTS-c as exercise mimetic and metabolic regulator (2022): MOTS-c in aged mice improved exercise capacity by 35% and restored insulin sensitivity to youthful levels.
- Decline of circulating MOTS-c with aging (2021): Plasma MOTS-c decreased by 50% between ages 20-60, correlating with declining metabolic health.
Compare MOTS-c
Community discussions about MOTS-c
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- Trying MOTS-c alongside my semaglutide titration – early notes - 7 comments
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- Ask the community about MOTS-c
Research and educational reference only. Not medical advice.