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NMN (Nicotinamide Mononucleotide)

Category: Anti-Aging. Status: Dietary compound (research ongoing).

A direct precursor to NAD+, a coenzyme central to cellular energy production and DNA repair that declines with age. Supplemented to raise NAD+ levels and support mitochondrial function and metabolic health.

How it works

NMN is converted to NAD+ via the NAD+ salvage pathway (through NMNAT enzymes). Higher NAD+ supports sirtuin activity, PARP-mediated DNA repair, and mitochondrial energy metabolism.

Key facts

  • Molecular weight: 334.22 Da
  • Half-life: Short; rapidly taken up and converted to NAD+
  • Bioavailability: Oral absorption reported; sublingual and injectable forms also used
  • Storage: Keep cool, dry, and away from light; refrigeration extends shelf life.

Dosing overview

  • Typical dose: 250-1000 mg per day
  • Frequency: Once daily
  • Duration: Ongoing
  • Route: Oral (capsule/sublingual)

Protocol notes

  • Common range is ~250-1000 mg once daily, often taken in the morning.
  • Some split larger doses or use sublingual forms for absorption.
  • Frequently paired with NAD+ boosters or longevity stacks.

Reported benefits

  • Raises cellular NAD+ levels
  • Supports mitochondrial energy production
  • Promotes DNA repair via sirtuins/PARPs
  • Studied for metabolic and vascular health

Possible side effects

  • Generally well tolerated
  • Mild flushing or nausea (uncommon)
  • GI upset at high doses
  • Long-term human data still limited

Research

  • NMN supplementation and metabolic health (2021): Improved muscle insulin sensitivity in prediabetic women in a randomized trial.
  • Safety of oral NMN in healthy adults (2022): Doses up to 900 mg/day raised blood NAD+ and were well tolerated.

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Community discussions about NMN

Research and educational reference only. Not medical advice.