Palmitoyl Tetrapeptide-7 (Palmitoyl Tetrapeptide-7 (Pal-GQPR))
A lipopeptide that reduces IL-6 secretion and inflammaging. Often paired with Pal-Tripeptide-1 as "Matrixyl 3000" for combined collagen-building and anti-inflammatory action.
How it works
Inhibits IL-6 release from keratinocytes and reduces inflammation-mediated MMP activation, preserving existing collagen while complementing Pal-GHK collagen building.
Key facts
- Molecular weight: 693 Da
- Half-life: 8-12 hours (topical)
- Bioavailability: Good (topical)
- Storage: Room temperature, stable in formulations.
Dosing overview
- Typical dose: 2-4% in formulation
- Frequency: 1-2x daily
- Duration: 8-16 weeks
- Route: Topical
Reported benefits
- Anti-inflammatory (skin)
- Reduces IL-6
- Prevents collagen degradation
- Combats inflammaging
Possible side effects
- Extremely well tolerated
- No significant reports
Research
- Anti-inflammatory effects of Pal-GQPR on UV-damaged skin (2021): Reduced UV-induced IL-6 by 55% and MMP-1 by 35% in irradiated keratinocytes.
- Inflammaging modulation by cosmeceutical peptides (2022): Significantly reduced inflammatory markers in chronological and photoaging clinical evaluation.
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Community discussions about Palmitoyl Tetrapeptide-7
- Confused about Matrixyl vs Palmitoyl Tetrapeptide-7 for skin stuff - 4 comments
- Combining GHK-Cu and Palmitoyl Tetrapeptide-7 for skin aging? - 3 comments
- Matrixyl 3000 actually worth it or just expensive moisturiser in a fancy bottle? - 4 comments
- Ask the community about Palmitoyl Tetrapeptide-7
Research and educational reference only. Not medical advice.