Palmitoyl Tetrapeptide-7 (Palmitoyl Tetrapeptide-7 (Pal-GQPR))
A lipopeptide that reduces IL-6 secretion and inflammaging. Often paired with Pal-Tripeptide-1 as "Matrixyl 3000" for combined collagen-building and anti-inflammatory action.
How it works
Inhibits IL-6 release from keratinocytes and reduces inflammation-mediated MMP activation, preserving existing collagen while complementing Pal-GHK collagen building.
Key facts
- Molecular weight: 693 Da
- Half-life: 8-12 hours (topical)
- Bioavailability: Good (topical)
- Storage: Room temperature, stable in formulations.
Dosing overview
- Typical dose: 2-4% in formulation
- Frequency: 1-2x daily
- Duration: 8-16 weeks
- Route: Topical
Reported benefits
- Anti-inflammatory (skin)
- Reduces IL-6
- Prevents collagen degradation
- Combats inflammaging
Possible side effects
- Extremely well tolerated
- No significant reports
Research
- Anti-inflammatory effects of Pal-GQPR on UV-damaged skin (2021): Reduced UV-induced IL-6 by 55% and MMP-1 by 35% in irradiated keratinocytes.
- Inflammaging modulation by cosmeceutical peptides (2022): Significantly reduced inflammatory markers in chronological and photoaging clinical evaluation.
Community reviews of Palmitoyl Tetrapeptide-7
- steady_state_stan rated it 5/5 - Noticed clear benefits within weeks: Added Palmitoyl Tetrapeptide-7 to my protocol about 2 weeks ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
- cycle_sage rated it 5/5 - Genuinely effective after 3 weeks: Been using Palmitoyl Tetrapeptide-7 for about 3 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- nomad_renee rated it 4/5 - less red face after long shifts: spent 4 months on this and anecdotally my skin redness just STOPPED, especially after those brutal 12 hour shifts at the pharmacy, felt much steadier lah. just my own experience though, probably a bit of placebo, but my face looks way less inflamed. only 4 stars cos it takes forever to see results.
- bac_water_betty rated it 5/5 - Worth adding to the protocol: Palmitoyl Tetrapeptide-7 has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you w
- jake777 rated it 4/5 - Less morning face puffiness, that was the win: After about 8 weeks on Palmitoyl Tetrapeptide-7, the main thing I noticed was less puffiness and that tired, inflamed look in the morning. I’m 20-something, on the West Coast, and I like anything that helps me look less beat up after firefighting work and training. Small caveat, the change was subtle, not dramatic.
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Research and educational reference only. Not medical advice.