Amlexanox (Amlexanox (TBK1/IKKε Inhibitor))
An anti-inflammatory compound that inhibits TBK1 and IKKε kinases, enzymes that create obesity-driven insulin resistance. Emerging in telemedicine for metabolic syndrome and stubborn weight loss.
How it works
Inhibits IKKε and TBK1 kinases that are upregulated in obesity, which normally suppress energy expenditure. Blocking these kinases restores thermogenesis and improves insulin sensitivity.
Key facts
- Molecular weight: 298.29 Da
- Half-life: ~3-4 hours
- Bioavailability: ~70% oral
- Storage: Room temperature.
Dosing overview
- Typical dose: 25-100 mg
- Frequency: 3x daily
- Duration: 8-12 weeks
- Route: Oral tablet
Protocol notes
- Metabolic protocols commonly use ~50 mg three times daily (the dose studied in obesity/diabetes trials).
- Run as an 8-12 week block alongside diet and activity, then reassess.
- Often stacked with a GLP-1 or 5-Amino-1MQ in metabolic protocols.
Reported benefits
- Increased energy expenditure
- Improved insulin sensitivity
- Weight loss
- Reduced inflammation
- Metabolic reset
Possible side effects
- GI upset
- Diarrhea
- Headache
- Dizziness
- Mouth irritation
Research
- Amlexanox in obese type 2 diabetes (2021): Improved insulin sensitivity by 25% and increased resting energy expenditure in 12-week randomized trial.
Compare Amlexanox
Community discussions about Amlexanox
- Thinking about adding amlexanox to my semaglutide routine - 6 comments
- Trying amlexanox alongside semaglutide, first 2 weeks and what I noticed - 0 comments
- Curious about Amlexanox for late‑night snacking – has anyone tried it? - 7 comments
- thinking about adding Amlexanox to my current setup - 3 comments
- Thoughts on the new Amlexanox update for metabolic reset - 4 comments
- Ask the community about Amlexanox
Research and educational reference only. Not medical advice.