RAD-140 (Testolone) (Testolone (RAD-140))
A potent selective androgen receptor modulator (SARM) studied for strong anabolic effects on muscle. It is not approved for human use, is banned in sport, and carries notable suppression and liver-stress concerns.
How it works
Acts as a strong, tissue-selective androgen receptor agonist in muscle and bone, driving anabolic signaling with a higher anabolic-to-androgenic ratio than testosterone in preclinical models.
Key facts
- Molecular weight: 393.83 Da
- Half-life: ~16-20 hours
- Bioavailability: Oral
- Storage: Keep cool, dry, and sealed; protect from light.
Dosing overview
- Typical dose: Commonly cited 5-15 mg/day (research)
- Frequency: Once daily
- Duration: Commonly cited 6-10 week cycles
- Route: Oral
Protocol notes
- Once-daily oral dosing is typical.
- Reported as more suppressive than Ostarine; users plan a recovery/PCT phase.
- Regular bloodwork (testosterone, lipids, liver markers) is strongly advised.
Reported benefits
- Strong lean muscle gains (research)
- Increased strength
- Studied originally for muscle wasting and breast cancer
- Bone-supportive signaling
Possible side effects
- Marked testosterone suppression
- Liver enzyme elevation
- Lowered HDL cholesterol
- Aggression/mood changes
- Potential hair shedding
Research
- RAD-140 preclinical anabolic profile (2011): Showed potent, tissue-selective anabolic activity in muscle with reduced prostate effects in primates.
Community reviews of RAD-140 (Testolone)
- biohack_bree rated it 5/5 - Genuinely effective after 3 weeks: Been using RAD-140 (Testolone) for about 3 weeks and the results are clear. Not overnight dramatic, but a steady, consistent improvement that became undeniable by the end of the first month. The mechanism makes sense based on what I have read in the literature, and my subjective experience matches the expected timeline. Benefits built gradually and plateaued at a good level. Side effects were minimal to none at the dose I used. Followed proper protocols for sourcing, storage, and administration. Would recommend to others who have done their research and have realistic expectations.
- subq_samantha rated it 4/5 - Worth adding to the protocol: RAD-140 (Testolone) has been a worthwhile addition. I am data-driven and tracked relevant markers before, during, and after. The improvement is measurable and correlates with the intervention timeline. What sets this apart from some compounds I have tried is the consistency. Benefits did not fluctuate wildly or disappear. They built up and maintained. That gives me confidence in the mechanism. Tolerance has been excellent. Nothing in my bloodwork or subjective experience raised any flags. This is the kind of compound that does its job quietly without causing problems. Exactly what you want.
- dose_math_derek rated it 5/5 - Noticed clear benefits within weeks: Added RAD-140 (Testolone) to my protocol about 3 months ago and it has earned its place. The benefits became noticeable around week 2-3 and have been consistent since. What I appreciate about this compound is the predictability. It does what the research suggests it should do, at roughly the timeline you would expect. No surprises, no dramatic swings, just steady improvement. No notable side effects to report at my dose. Sourcing is always the challenge with research compounds, insist on third-party testing. Storage and reconstitution per standard protocols. Plan to continue.
Compare RAD-140 (Testolone)
Research and educational reference only. Not medical advice.