MGF (Mechano Growth Factor) vs RAD-140 (Testolone)
A side-by-side research comparison of MGF (Mechano Growth Factor) and RAD-140 (Testolone) across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | MGF (Mechano Growth Factor) | RAD-140 (Testolone) |
|---|---|---|
| Full name | Mechano Growth Factor (IGF-1Ec splice variant) | Testolone (RAD-140) |
| Category | Muscle Growth | Muscle Growth |
| Status | Research compound | Investigational (not approved; banned in sport) |
| Mechanism | Unique E-domain activates quiescent satellite cells for proliferation. Distinct from IGF-1Ea which drives differentiation. PEGylated form extends short half-life. | Acts as a strong, tissue-selective androgen receptor agonist in muscle and bone, driving anabolic signaling with a higher anabolic-to-androgenic ratio than testosterone in preclinical models. |
| Molecular weight | 2,867 Da (synthetic fragment) | 393.83 Da |
| Half-life | 5-7 min (native) / 24-48h (PEGylated) | ~16-20 hours |
| Bioavailability | High (local IM) | Oral |
| Typical dose | 100-200 mcg PEG-MGF | Commonly cited 5-15 mg/day (research) |
| Frequency | 2-3x per week | Once daily |
| Route | Intramuscular (local) | Oral |
MGF (Mechano Growth Factor) reported benefits
- Satellite cell activation
- Muscle-specific growth
- Repair response enhancement
- Synergistic with training
- Local hypertrophy
RAD-140 (Testolone) reported benefits
- Strong lean muscle gains (research)
- Increased strength
- Studied originally for muscle wasting and breast cancer
- Bone-supportive signaling
Related comparisons
Research and educational reference only. Not medical advice.