Sermorelin (Sermorelin Acetate (GHRH 1-29))
The biologically active fragment of GHRH (first 29 amino acids). Previously FDA-approved for GH deficiency in children. Stimulates natural pulsatile GH release. Now available through compounding pharmacies.
How it works
Binds GHRH receptors on anterior pituitary via cAMP-PKA pathway. Preserves natural feedback regulation and pulsatility unlike exogenous HGH.
Key facts
- Molecular weight: 3,358 Da
- Half-life: 10-20 minutes
- Bioavailability: Moderate (SubQ)
- Storage: Lyophilized: 2-8°C. Reconstituted: 2-8°C for 14 days.
Dosing overview
- Typical dose: 200-300 mcg
- Frequency: Once daily before bed
- Duration: 3-6 months
- Route: Subcutaneous injection
Protocol notes
- Single nightly dose of 200-300 mcg, injected fasted before sleep.
- Run for 3-6 months since it works by gently restoring natural GH rhythm rather than spiking it.
Reported benefits
- Natural GH pulsatility preserved
- Improved sleep quality
- Body composition improvement
- Skin elasticity
- Long safety record
Possible side effects
- Injection site reaction
- Flushing
- Headache
- Dizziness
Research
- Long-term sermorelin therapy for adult GH deficiency (2018): Six months increased IGF-1 by 30%, improved body composition and sleep quality without suppressing endogenous GH axis.
- Sermorelin vs somatotropin for GH replacement (2020): Achieved 70% of HGH effects on IGF-1 with superior safety profile and preserved pituitary function.
Compare Sermorelin
Community discussions about Sermorelin
- topol on peptides, finally someone saying the quiet part out loud - 6 comments
- Sermorelin timing with a healing block, is bedtime still best? - 4 comments
- SciAm piece asking whether GH peptides actually do anything for ageing - 5 comments
- First time with Sermorelin: How to read a simple protocol? - 4 comments
- Sermorelin + BPC-157 nightly stack for tendon recovery – looking for timing feedback - 6 comments
- Ask the community about Sermorelin
Research and educational reference only. Not medical advice.