TB4-Frag (TBF) vs Thymosin Beta-4
A side-by-side research comparison of TB4-Frag (TBF) and Thymosin Beta-4 across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | TB4-Frag (TBF) | Thymosin Beta-4 |
|---|---|---|
| Full name | Thymosin Beta-4 Fragment | Thymosin Beta-4 (Full Length) |
| Category | Healing & Recovery | Healing & Recovery |
| Status | Research compound | Research compound |
| Mechanism | Retains the actin-sequestering motif of full TB-4, promoting cell migration, angiogenesis, and reduction of inflammation at injury sites. The shorter sequence may offer improved bioavailability and targeted tissue penetration. | Sequesters G-actin to regulate cytoskeleton dynamics, promotes stem cell differentiation, and activates anti-inflammatory and anti-apoptotic pathways. |
| Molecular weight | ~1,200-1,800 Da (fragment) | 4921 Da |
| Half-life | ~2-4 hours | ~6-8 hours |
| Bioavailability | High subcutaneous absorption | ~95% subcutaneous |
| Typical dose | 200-750 mcg per dose | 1-5 mg |
| Frequency | Daily or every other day | 2-3x per week |
| Route | Subcutaneous injection | Subcutaneous injection |
TB4-Frag (TBF) reported benefits
- Wound and tissue healing
- Reduced inflammation
- Potential improved tissue penetration vs full TB-4
- Support for tendon and muscle repair
- Angiogenesis promotion
Thymosin Beta-4 reported benefits
- Comprehensive tissue repair
- Cardiac regeneration
- Neurological recovery
- Corneal healing
- Anti-fibrotic effects
Related comparisons
Research and educational reference only. Not medical advice.