Thymalin (Thymalin (Thymus Extract Peptide))
A polypeptide complex extracted from calf thymus that restores immune function. Used in Russian medicine for immunodeficiency states and as an adjunct in cancer immunotherapy.
How it works
Contains bioactive thymic peptides that regulate T-lymphocyte differentiation, restore T-helper/T-suppressor ratios, and enhance phagocyte activity and interferon production.
Key facts
- Molecular weight: ~1000-5000 Da (complex mixture)
- Half-life: ~4-6 hours
- Bioavailability: ~80% intramuscular
- Storage: Lyophilized: 2-8°C. Reconstituted: use immediately.
Dosing overview
- Typical dose: 5-10 mg
- Frequency: Daily for 5-10 days
- Duration: 5-10 day cycles, 1-3x/year
- Route: Intramuscular injection
Protocol notes
- Run as a short course: ~5-10 mg intramuscularly once daily for 5-10 consecutive days.
- Courses are repeated a few times per year rather than dosed continuously (the "bioregulator" pattern).
- Often paired with Epithalon in longevity protocols (immune + pineal support).
Reported benefits
- Immune reconstitution
- T-cell ratio normalization
- Interferon production
- Anti-tumor immunity support
Possible side effects
- Injection site pain
- Mild allergic reaction (rare)
- Transient fatigue
Research
- Thymalin in cancer immunotherapy (2018): Improved T-cell counts and reduced infection rates in immunocompromised cancer patients.
- Thymic peptides and longevity (2020): Combined thymalin and epithalon reduced mortality by 28% in elderly patients over 12 years.
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Research and educational reference only. Not medical advice.