Ayahuasca vs DOI
A side-by-side research comparison of Ayahuasca and DOI across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ayahuasca | DOI |
|---|---|---|
| Full name | Ayahuasca (DMT + MAO inhibitor brew) | 2,5-Dimethoxy-4-iodoamphetamine |
| Category | Psychedelics | Psychedelics |
| Status | Traditional/ceremonial; research compound | Schedule I (research compound) |
| Mechanism | The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors. | A potent, long-acting 5-HT2A receptor agonist; a standard pharmacology research tool. |
| Molecular weight | Mixture (no single value) | 321.16 g/mol |
| Half-life | Several hours (extended by MAO inhibition) | Long |
| Bioavailability | Oral | Oral |
| Typical dose | Brew-based, varies by preparation | Varies by individual and setting |
| Frequency | Ceremonial or occasional study sessions | Occasional |
| Route | Oral brew | Oral |
Ayahuasca reported benefits
- Studied for treatment-resistant depression
- Explored for grief and trauma
- Long history of ceremonial use
- May produce lasting shifts in outlook
DOI reported benefits
- Key laboratory research tool
- Long-acting psychedelic
- Used to map 5-HT2A receptors
- DOx family
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Research and educational reference only. Not medical advice.