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Ayahuasca (Ayahuasca (DMT + MAO inhibitor brew))

Category: Psychedelics. Status: Traditional/ceremonial; research compound.

A traditional Amazonian plant brew combining DMT with a natural MAO inhibitor so the DMT stays active when taken by mouth. Studied for depression and trauma, and used ceremonially for centuries.

How it works

The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors.

Key facts

  • Molecular weight: Mixture (no single value)
  • Half-life: Several hours (extended by MAO inhibition)
  • Bioavailability: Oral
  • Storage: Traditional/research settings only.

Dosing overview

  • Typical dose: Brew-based, varies by preparation
  • Frequency: Ceremonial or occasional study sessions
  • Duration: Acute effects last 4-6 hours
  • Route: Oral brew

Protocol notes

  • Drunk as a bitter brew in a guided ceremony, often at night with a facilitator or shaman.
  • People follow a "dieta" beforehand, avoiding certain foods, alcohol and many medications (especially antidepressants).
  • Vomiting (the "purge") is common and treated as part of the process.
  • Effects build over 30-60 minutes and last several hours, so the ceremony runs through the night.

Reported benefits

  • Studied for treatment-resistant depression
  • Explored for grief and trauma
  • Long history of ceremonial use
  • May produce lasting shifts in outlook

Possible side effects

  • Strong nausea and vomiting ("the purge")
  • Dangerous interactions with SSRIs and certain foods
  • Anxiety or fear
  • Raised heart rate and blood pressure

Research

  • Ayahuasca for treatment-resistant depression (2019): A single dose produced significant antidepressant effects compared with placebo in a controlled trial.

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Research and educational reference only. Not medical advice.