Ayahuasca vs Mescaline
A side-by-side research comparison of Ayahuasca and Mescaline across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ayahuasca | Mescaline |
|---|---|---|
| Full name | Ayahuasca (DMT + MAO inhibitor brew) | Mescaline (from peyote and San Pedro cactus) |
| Category | Psychedelics | Psychedelics |
| Status | Traditional/ceremonial; research compound | Schedule I (research compound) |
| Mechanism | The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors. | Activates serotonin 5-HT2A receptors, producing long-lasting changes in perception and mood. It is a phenethylamine rather than a tryptamine. |
| Molecular weight | Mixture (no single value) | 211.26 g/mol |
| Half-life | Several hours (extended by MAO inhibition) | ~6 hours |
| Bioavailability | Oral | Oral |
| Typical dose | Brew-based, varies by preparation | Several hundred milligrams (study and traditional use) |
| Frequency | Ceremonial or occasional study sessions | Occasional or ceremonial |
| Route | Oral brew | Oral |
Ayahuasca reported benefits
- Studied for treatment-resistant depression
- Explored for grief and trauma
- Long history of ceremonial use
- May produce lasting shifts in outlook
Mescaline reported benefits
- Long history of ceremonial use
- Survey data links use to wellbeing
- Renewed research interest
- Distinct phenethylamine profile
Related comparisons
Research and educational reference only. Not medical advice.