Ayahuasca vs Salvinorin A
A side-by-side research comparison of Ayahuasca and Salvinorin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ayahuasca | Salvinorin A |
|---|---|---|
| Full name | Ayahuasca (DMT + MAO inhibitor brew) | Salvinorin A (Salvia divinorum) |
| Category | Psychedelics | Psychedelics |
| Status | Traditional/ceremonial; research compound | Varies by region; research compound |
| Mechanism | The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors. | Activates kappa-opioid receptors (not serotonin receptors), which makes its effects unlike LSD or psilocybin. |
| Molecular weight | Mixture (no single value) | 432.46 g/mol |
| Half-life | Several hours (extended by MAO inhibition) | Very short |
| Bioavailability | Oral | Oral |
| Typical dose | Brew-based, varies by preparation | Varies by individual and setting |
| Frequency | Ceremonial or occasional study sessions | Occasional |
| Route | Oral brew | Smoked, vaporized or held in the mouth |
Ayahuasca reported benefits
- Studied for treatment-resistant depression
- Explored for grief and trauma
- Long history of ceremonial use
- May produce lasting shifts in outlook
Salvinorin A reported benefits
- Unique kappa-opioid mechanism
- Very short experience
- Long traditional Mazatec use
- Of interest for depression research
Related comparisons
Research and educational reference only. Not medical advice.