GDF-11 vs Glutathione
A side-by-side research comparison of GDF-11 and Glutathione across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GDF-11 | Glutathione |
|---|---|---|
| Full name | Growth Differentiation Factor 11 | L-Glutathione (Reduced) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Supplement / Injectable |
| Mechanism | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. | Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA. |
| Molecular weight | 12,500 Da | 307.32 Da |
| Half-life | 6-8 hours | ~1.5-2 hours (IV/IM) |
| Bioavailability | Moderate (SubQ/IV) | ~95% injectable; low oral (~3%) |
| Typical dose | 0.1-0.5 mg/kg (research) | 200-600 mg |
| Frequency | Daily (animal studies) | 1-3x per week |
| Route | Subcutaneous | IV push, IM injection, or nebulized |
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
Glutathione reported benefits
- Powerful antioxidant protection
- Liver detoxification support
- Skin brightening
- Immune system support
- Anti-aging cellular protection
- Heavy metal chelation
Related comparisons
Research and educational reference only. Not medical advice.