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Glutathione (L-Glutathione (Reduced))

Category: Anti-Aging. Status: Supplement / Injectable.

The master antioxidant of the body, a tripeptide found in every cell. Injectable glutathione is a telemedicine staple for detoxification, skin brightening, and cellular protection against oxidative stress.

How it works

Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA.

Key facts

  • Molecular weight: 307.32 Da
  • Half-life: ~1.5-2 hours (IV/IM)
  • Bioavailability: ~95% injectable; low oral (~3%)
  • Storage: Reconstituted: 2-8°C. Use within 30 days.

Dosing overview

  • Typical dose: 200-600 mg
  • Frequency: 1-3x per week
  • Duration: Ongoing
  • Route: IV push, IM injection, or nebulized

Protocol notes

  • IV push: ~600-1200 mg pushed slowly, 1-2x per week, is a common clinic protocol.
  • IM injection: ~200-400 mg per dose for at-home use, 2-3x per week.
  • For skin-brightening goals, it is often paired with vitamin C in the same session.

Reported benefits

  • Powerful antioxidant protection
  • Liver detoxification support
  • Skin brightening
  • Immune system support
  • Anti-aging cellular protection
  • Heavy metal chelation

Possible side effects

  • Injection site pain
  • Mild cramping
  • Zinc depletion (long-term)
  • Bloating
  • Rare: sulfite sensitivity

Research

  • Glutathione supplementation and aging biomarkers (2022): IV glutathione reduced oxidative stress markers by 45% and improved mitochondrial function scores in elderly patients.
  • Glutathione in skin health (2021): Consistent administration showed measurable skin lightening and improved melanin distribution over 12 weeks.

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Research and educational reference only. Not medical advice.