GDF-11 vs GlyNAC
A side-by-side research comparison of GDF-11 and GlyNAC across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GDF-11 | GlyNAC |
|---|---|---|
| Full name | Growth Differentiation Factor 11 | Glycine + N-Acetylcysteine |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | OTC supplement combination |
| Mechanism | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. |
| Molecular weight | 12,500 Da | Glycine 75.07 Da / NAC 163.19 Da |
| Half-life | 6-8 hours | Glycine ~1 h; NAC ~6 h |
| Bioavailability | Moderate (SubQ/IV) | Glycine high; NAC ~4-10% but effective as cysteine donor |
| Typical dose | 0.1-0.5 mg/kg (research) | Glycine ~100 mg/kg + NAC ~100 mg/kg per day |
| Frequency | Daily (animal studies) | Split 1-2x daily |
| Route | Subcutaneous | Oral (powder or capsule) |
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
Related comparisons
Research and educational reference only. Not medical advice.