GDF-11 vs Urolithin A
A side-by-side research comparison of GDF-11 and Urolithin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GDF-11 | Urolithin A |
|---|---|---|
| Full name | Growth Differentiation Factor 11 | Urolithin A (Mitophagy Activator) |
| Category | Anti-Aging | Anti-Aging |
| Status | Research compound | Dietary compound (clinical studies) |
| Mechanism | Signals through activin type II receptors and SMAD2/3 to restore stem cell function, promote neurogenesis, and improve vascular remodeling in the context of aging. | Stimulates mitophagy - the selective recycling of damaged mitochondria - improving mitochondrial quality and energy efficiency in muscle and other tissues. |
| Molecular weight | 12,500 Da | 228.20 Da |
| Half-life | 6-8 hours | Several hours |
| Bioavailability | Moderate (SubQ/IV) | Oral; bypasses the need for the gut bacteria many people lack |
| Typical dose | 0.1-0.5 mg/kg (research) | 500-1000 mg per day |
| Frequency | Daily (animal studies) | Once daily |
| Route | Subcutaneous | Oral |
GDF-11 reported benefits
- Potential tissue rejuvenation
- Neurogenesis stimulation
- Cardiac hypertrophy reversal
- Muscle stem cell activation
- Vascular remodeling
Urolithin A reported benefits
- Improves mitochondrial function (mitophagy)
- Increased muscle endurance
- Cellular energy support
- Studied for healthy aging
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Research and educational reference only. Not medical advice.