Glutathione vs GlyNAC
A side-by-side research comparison of Glutathione and GlyNAC across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Glutathione | GlyNAC |
|---|---|---|
| Full name | L-Glutathione (Reduced) | Glycine + N-Acetylcysteine |
| Category | Anti-Aging | Anti-Aging |
| Status | Supplement / Injectable | OTC supplement combination |
| Mechanism | Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA. | Glycine and NAC (a cysteine donor) are the rate-limiting precursors for glutathione. Replenishing both restores intracellular glutathione, lowers oxidative stress, improves mitochondrial fuel oxidation, and reduces inflammation and insulin resistance. |
| Molecular weight | 307.32 Da | Glycine 75.07 Da / NAC 163.19 Da |
| Half-life | ~1.5-2 hours (IV/IM) | Glycine ~1 h; NAC ~6 h |
| Bioavailability | ~95% injectable; low oral (~3%) | Glycine high; NAC ~4-10% but effective as cysteine donor |
| Typical dose | 200-600 mg | Glycine ~100 mg/kg + NAC ~100 mg/kg per day |
| Frequency | 1-3x per week | Split 1-2x daily |
| Route | IV push, IM injection, or nebulized | Oral (powder or capsule) |
Glutathione reported benefits
- Powerful antioxidant protection
- Liver detoxification support
- Skin brightening
- Immune system support
- Anti-aging cellular protection
- Heavy metal chelation
GlyNAC reported benefits
- Restores glutathione levels
- Improves mitochondrial function
- Lowers oxidative stress and inflammation
- Better insulin sensitivity
- Improved strength and cognition (elderly)
- Sleep support (glycine)
Related comparisons
Research and educational reference only. Not medical advice.