Glutathione vs NR
A side-by-side research comparison of Glutathione and NR across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Glutathione | NR |
|---|---|---|
| Full name | L-Glutathione (Reduced) | Nicotinamide Riboside |
| Category | Anti-Aging | Anti-Aging |
| Status | Supplement / Injectable | Dietary compound (clinical studies) |
| Mechanism | Directly neutralizes free radicals, regenerates vitamins C and E, supports phase II liver detoxification, maintains cellular redox balance, and protects mitochondrial DNA. | Converted to NMN and then NAD+ via the salvage pathway (NRK enzymes). Higher NAD+ supports sirtuins, DNA repair, and mitochondrial energy production. |
| Molecular weight | 307.32 Da | 255.25 Da |
| Half-life | ~1.5-2 hours (IV/IM) | Short; rapidly converted to NAD+ |
| Bioavailability | ~95% injectable; low oral (~3%) | Oral absorption well documented |
| Typical dose | 200-600 mg | 250-1000 mg per day |
| Frequency | 1-3x per week | Once daily |
| Route | IV push, IM injection, or nebulized | Oral |
Glutathione reported benefits
- Powerful antioxidant protection
- Liver detoxification support
- Skin brightening
- Immune system support
- Anti-aging cellular protection
- Heavy metal chelation
NR reported benefits
- Raises NAD+ levels
- Supports mitochondrial energy
- Well-studied oral safety
- Studied for metabolic and cardiovascular health
Related comparisons
Research and educational reference only. Not medical advice.