NSI-189 vs Synapsin
A side-by-side research comparison of NSI-189 and Synapsin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | NSI-189 | Synapsin |
|---|---|---|
| Full name | NSI-189 Phosphate (Neurogenic Compound) | Synapsin Nasal Spray (RG3 + NAD+ + Methylcobalamin) |
| Category | Cognitive & Nootropic | Cognitive & Nootropic |
| Status | Investigational | Compounded medication |
| Mechanism | Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI. | Rg3 reduces neuroinflammation and protects neurons. NAD+ supports mitochondrial function and sirtuin activation in brain cells. Methylcobalamin provides methylation support and myelin repair. Nasal route bypasses BBB for direct CNS delivery. |
| Molecular weight | 366.4 Da | Combination compound |
| Half-life | 18-22 hours | Variable (nasal depot effect) |
| Bioavailability | High (oral) | ~60-80% nasal (direct CNS access) |
| Typical dose | 40-80 mg | 1-2 sprays per nostril |
| Frequency | Once daily | 1-2x daily |
| Route | Oral | Intranasal spray |
NSI-189 reported benefits
- Hippocampal neurogenesis
- Measurable brain volume increase
- Cognitive enhancement
- Antidepressant effects
- Long-term neural benefit
Synapsin reported benefits
- Improved mental clarity
- Reduced brain fog
- Neuroprotection
- Enhanced focus
- Nerve repair support
- Anti-neuroinflammatory
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Research and educational reference only. Not medical advice.