NSI-189 (NSI-189 Phosphate (Neurogenic Compound))
A small molecule stimulating hippocampal neurogenesis. Developed for MDD, it increases hippocampal volume measurable by MRI and improves cognition independent of mood effects.
How it works
Stimulates hippocampal neural stem cell proliferation and differentiation via Akt/CREB/BDNF signaling. Increases hippocampal volume visible on MRI.
Key facts
- Molecular weight: 366.4 Da
- Half-life: 18-22 hours
- Bioavailability: High (oral)
- Storage: Room temperature, protected from moisture.
Dosing overview
- Typical dose: 40-80 mg
- Frequency: Once daily
- Duration: 8-12 weeks
- Route: Oral
Reported benefits
- Hippocampal neurogenesis
- Measurable brain volume increase
- Cognitive enhancement
- Antidepressant effects
- Long-term neural benefit
Possible side effects
- Headache
- Insomnia
- Agitation
- Dizziness
- Suicidal ideation (monitor)
Research
- NSI-189 Phase 2 in MDD (2019): Significant cognitive improvements (SDR, CogScreen) vs placebo but missed primary depression endpoint.
- Hippocampal volume changes with NSI-189 (2020): 4% hippocampal volume increase after 12 weeks vs 1% decrease in placebo on MRI.
Compare NSI-189
Community discussions about NSI-189
- Looking at the latest NSI-189 hippocampal growth data – thoughts? - 5 comments
- Did NSI-189 Give Me a Memory Boost or Just Headaches? - 6 comments
- NSI-189 + Dihexa: my 4‑week memory boost test - 9 comments
- NSI-189 headache, anyone else? Trying to figure out if it tapers off - 4 comments
- NSI-189 phosphate, six weeks in, my honest take on the hippocampal volume claim - 6 comments
- Ask the community about NSI-189
Research and educational reference only. Not medical advice.