Pregnenolone vs Testosterone Cypionate
A side-by-side research comparison of Pregnenolone and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Pregnenolone | Testosterone Cypionate |
|---|---|---|
| Full name | Pregnenolone (Mother Hormone) | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | FDA Approved (Schedule III) |
| Mechanism | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | 316.48 Da | 412.61 Da |
| Half-life | ~1-3 hours (oral) | ~8 days |
| Bioavailability | ~60% oral | ~100% (intramuscular) |
| Typical dose | 50-100 mg | 100-200 mg |
| Frequency | Daily (morning) | Weekly or split biweekly |
| Route | Oral capsule or sublingual | Intramuscular or subcutaneous injection |
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
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Research and educational reference only. Not medical advice.