DHEA vs Pregnenolone
A side-by-side research comparison of DHEA and Pregnenolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DHEA | Pregnenolone |
|---|---|---|
| Full name | Dehydroepiandrosterone | Pregnenolone (Mother Hormone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | OTC supplement / Prescribed | OTC supplement / Prescribed |
| Mechanism | Serves as a precursor to both testosterone and estrogen. Also acts directly on DHEA-specific receptors, supports immune function, neurosteroid activity, and cellular metabolism. | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. |
| Molecular weight | 288.42 Da | 316.48 Da |
| Half-life | 15-38 hours | ~1-3 hours (oral) |
| Bioavailability | ~100% oral | ~60% oral |
| Typical dose | 25-100 mg | 50-100 mg |
| Frequency | Daily (morning) | Daily (morning) |
| Route | Oral capsule or topical cream | Oral capsule or sublingual |
DHEA reported benefits
- Hormone precursor support
- Improved energy levels
- Bone density support
- Cognitive function
- Immune enhancement
- Anti-aging
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
Related comparisons
Research and educational reference only. Not medical advice.