HCG vs Pregnenolone
A side-by-side research comparison of HCG and Pregnenolone across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | HCG | Pregnenolone |
|---|---|---|
| Full name | Human Chorionic Gonadotropin | Pregnenolone (Mother Hormone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | FDA Approved | OTC supplement / Prescribed |
| Mechanism | Binds LH/CG receptors on Leydig cells, stimulating intratesticular testosterone synthesis and maintaining spermatogenesis via local paracrine signaling independent of pituitary FSH/LH. | Acts as the primary substrate for steroidogenesis (cortisol, DHEA, progesterone, testosterone, estrogen). Also functions as a neurosteroid, enhancing memory and NMDA receptor activity. |
| Molecular weight | ~36,700 Da | 316.48 Da |
| Half-life | ~33 hours | ~1-3 hours (oral) |
| Bioavailability | ~100% (subcutaneous/intramuscular) | ~60% oral |
| Typical dose | 500-1000 IU | 50-100 mg |
| Frequency | 2-3x per week | Daily (morning) |
| Route | Subcutaneous injection | Oral capsule or sublingual |
HCG reported benefits
- Preserved testicular size
- Maintained fertility on TRT
- Intratesticular testosterone
- Improved mood (neurosteroid support)
- Pregnenolone/DHEA maintenance
Pregnenolone reported benefits
- Hormone precursor balance
- Memory enhancement
- Mood improvement
- Joint support
- Myelin sheath repair
- Stress resilience
Related comparisons
Research and educational reference only. Not medical advice.