Apigenin Research Guide

Full name: Apigenin (Flavone)

A flavone found in chamomile and parsley, popularized by longevity researchers as part of an evening sleep stack. Biohackers use it for sleep onset, relaxation, and its NAD-preserving and anti-inflammatory properties.

How Apigenin Works

Binds benzodiazepine sites on GABA-A receptors for mild anxiolytic and sedative effects, and inhibits CD38, an NAD-consuming enzyme, thereby helping preserve cellular NAD+ levels. Also provides antioxidant and anti-inflammatory activity.

Dosing Protocol

• Typical dose: 50 mg per day
• Frequency: Once daily (evening)
• Duration: Ongoing
• Route: Oral capsule

Reported Benefits

• Supports sleep onset
• Mild anxiolytic/relaxation
• CD38 inhibition (NAD+ preservation)
• Antioxidant and anti-inflammatory
• Potential anti-cancer research interest

Potential Side Effects

• Mild drowsiness
• Rare GI upset
• Possible additive sedation with other sleep aids
• Chamomile-allergy caution

Research Citations

1. Apigenin inhibits CD38 and preserves NAD+ (2013) - Apigenin inhibited CD38, raising intracellular NAD+ and improving metabolic markers in animal models.
2. Apigenin GABA-A modulation (2019) - Demonstrated anxiolytic and mild sedative effects via benzodiazepine-site GABA-A binding.

Related Sleep & Recovery Compounds

• DSIP - Full Profile
• CPC-1598 - Full Profile
• Magnesium L-Threonate - Full Profile
• Melatonin - Full Profile

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