Ayahuasca Research Guide

Full name: Ayahuasca (DMT + MAO inhibitor brew)

A traditional Amazonian plant brew combining DMT with a natural MAO inhibitor so the DMT stays active when taken by mouth. Studied for depression and trauma, and used ceremonially for centuries.

How Ayahuasca Works

The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors.

Dosing Protocol

• Typical dose: Brew-based, varies by preparation
• Frequency: Ceremonial or occasional study sessions
• Duration: Acute effects last 4-6 hours
• Route: Oral brew

Reported Benefits

• Studied for treatment-resistant depression
• Explored for grief and trauma
• Long history of ceremonial use
• May produce lasting shifts in outlook

Potential Side Effects

• Strong nausea and vomiting ("the purge")
• Dangerous interactions with SSRIs and certain foods
• Anxiety or fear
• Raised heart rate and blood pressure

Research Citations

1. Ayahuasca for treatment-resistant depression (2019) - A single dose produced significant antidepressant effects compared with placebo in a controlled trial.

Related Psychedelics Compounds

• MDMA - Full Profile
• Psilocybin - Full Profile
• LSD - Full Profile
• Ibogaine - Full Profile
• DMT - Full Profile
• 5-MeO-DMT - Full Profile

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